CYP1A2

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is agene
is mentioned by
Full namecytochrome P450, family 1, subfamily A, polypeptide 2
EntrezGene1544
PheGenI1544
VariationViewer1544
ClinVarCYP1A2
dbSNP1544
SADR1544
HugeNav1544
CYPANCcyp1a2
wikipediaCYP1A2
googleCYP1A2
gopubmedCYP1A2
EVSCYP1A2
HEFalMpCYP1A2
23andMeCYP1A2
UniProtP05177
EnsemblENSG00000140505
OMIM124060
EVSCYP1A2
# SNPs15
 Max MagnitudeChromosome positionSummary
Rs12720461274,749,010
Rs206952574,748,031
Rs2069526074,749,000
Rs2470890074,755,085
Rs247230474,751,897
Rs28399424274,754,828
Rs3569413674,747,272
Rs55889066074,753,234
Rs56276455074,751,854
Rs72547511074,749,863
Rs72547513274,750,296
Rs72547515074,752,211
Rs72547516074,752,237
Rs72547517074,754,904
Rs7625512.574,749,576
The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. One well known substrate of CYP1A2 is caffeine; individuals who are carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers. The same amount of caffeine will therefore tend to have more stimulating effect on CYP1A2 slow metabolizers than on CYP1A2 fast metabolizers.

CYP1A2 can also be stimulated or inhibited by numerous medications and food-drug interactions. Fluoroquinolones, for example, are both metabolized by, and inhibit, the CYP1A2 enyzyme. This can slow the breakdown of caffeine, for example, leading to caffeine overstimulation. Conversely, smoking is a well-known activator of CYP1A2 (especially the CYP1A2*1F form), resulting in faster breakdown of drugs metabolized by CYP1A2 and the possibility of insufficient drug concentrations in the body to yield much therapeutic benefit.

Ciprofloxacin is metabolized by CYP1A2

Alleles of CYP1A2 include:

Allele Name Rs# Comments Platforms
CYP1A2*1 n/a the prototypical allele
CYP1A2*1C rs2069514 decreased activity; also known as -3860G>A 23andMe v3
CYP1A2*1D rs35694136
CYP1A2*1F rs762551 increased activity; also known as -163C>A 23andMe v1, 23andMe v2, 23andMe v3, Illumina Human 1M, 23andMe v4
CYP1A2*1K_-729C>T rs12720461 decreased activity 23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M, 23andMe v4
CYP1A2*1K_-739T>G rs2069526 apparently decreased activity 23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M, 23andMe v4
CYP1A2*2_63C>G
CYP1A2*3 rs56276455 decreased activity; also known as D348N 23andMe v3, 23andMe v4
CYP1A2*4 rs72547516 decreased activity; also known as I386F 23andMe v3, 23andMe v4
CYP1A2*5 rs55889066 also known as C406Y 23andMe v3, 23andMe v4
CYP1A2*6 rs28399424 decreased activity; also known as R431W 23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M, 23andMe v4
CYP1A2*7_3534G>A decreased activity; may be 3533G>A
CYP1A2*8 rs72547517 also known as R456H 23andMe v3, 23andMe v4
CYP1A2*11 rs72547513 also known as F186L 23andMe v3, 23andMe v4
CYP1A2*15 rs72547511 also known as P42R
CYP1A2*16 rs72547515 also known as R377Q 23andMe v3, 23andMe v4
CYP1A2_1545T>C rs2470890 23andMe v2, 23andMe v3, Affy GenomeWide 6, 23andMe v4

Promethease detects these via gs157, gs158 and gs159