CYP1A2

is a	gene
is	mentioned by
Full name	cytochrome P450, family 1, subfamily A, polypeptide 2
EntrezGene	1544
PheGenI	1544
VariationViewer	1544
dbSNP	1544
SADR	1544
HugeNav	1544
CYPANC	cyp1a2
wikipedia	CYP1A2
google	CYP1A2
gopubmed	CYP1A2
EVS	CYP1A2
HEFalMp	CYP1A2
23andMe	CYP1A2
UniProt	P05177
Ensembl	ENSG00000140505
OMIM	124060
EVS	CYP1A2
# SNPs	15

	Max Magnitude	Chromosome position	Summary
Rs12720461	2	75,041,351
Rs2069525		75,040,372
Rs2069526	0	75,041,341
Rs2470890	0	75,047,426
Rs2472304		75,044,238
Rs28399424	2	75,047,169
Rs35694136		75,039,613
Rs55889066	0	75,045,575
Rs56276455	0	75,044,195
Rs72547511	0	75,042,204
Rs72547513	2	75,042,637
Rs72547515	0	75,044,552
Rs72547516	0	75,044,578
Rs72547517	0	75,047,245
Rs762551	2.5	75,041,917

The CYP1A2 gene encodes a member of the cytochrome p450 family of proteins, which metabolize nutrients and drugs. One well known substrate of CYP1A2 is caffeine; individuals who are carry one or more CYP1A2*1C alleles are "slow" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "fast" caffeine metabolizers. The same amount of caffeine will therefore tend to have more stimulating effect on CYP1A2 slow metabolizers than on CYP1A2 fast metabolizers.

CYP1A2 can also be stimulated or inhibited by numerous medications and food-drug interactions. Fluoroquinolones, for example, are both metabolized by, and inhibit, the CYP1A2 enyzyme. This can slow the breakdown of caffeine, for example, leading to caffeine overstimulation. Conversely, smoking is a well-known activator of CYP1A2 (especially the CYP1A2*1F form), resulting in faster breakdown of drugs metabolized by CYP1A2 and the possibility of insufficient drug concentrations in the body to yield much therapeutic benefit.

Ciprofloxacin is metabolized by CYP1A2

Alleles of CYP1A2 include:

Allele Name	Rs#	Comments	Platforms
CYP1A2*1	n/a	the prototypical allele
CYP1A2*1C	rs2069514	decreased activity; also known as -3860G>A	23andMe v3
CYP1A2*1D	rs35694136
CYP1A2*1F	rs762551	increased activity; also known as -163C>A	23andMe v1, 23andMe v2, 23andMe v3, Illumina Human 1M
CYP1A2*1K_-729C>T	rs12720461	decreased activity	23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M
CYP1A2*1K_-739T>G	rs2069526	apparently decreased activity	23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M
CYP1A2*2_63C>G
CYP1A2*3	rs56276455	decreased activity; also known as D348N	23andMe v3
CYP1A2*4	rs72547516	decreased activity; also known as I386F	23andMe v3
CYP1A2*5	rs55889066	also known as C406Y	23andMe v3
CYP1A2*6	rs28399424	decreased activity; also known as R431W	23andMe v1, 23andMe v2, 23andMe v3, FTDNA2, HumanOmni1Quad, Illumina Human 1M
CYP1A2*7_3534G>A		decreased activity; may be 3533G>A
CYP1A2*8	rs72547517	also known as R456H	23andMe v3
CYP1A2*11	rs72547513	also known as F186L	23andMe v3
CYP1A2*15	rs72547511	also known as P42R
CYP1A2*16	rs72547515	also known as R377Q	23andMe v3
CYP1A2_1545T>C	rs2470890		23andMe v2, 23andMe v3, Affy GenomeWide 6

Promethease detects these via gs157, gs158 and gs159