rs9951307
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | 0 | 0.10 decreased risk for brain edema after a stroke |
| (G;G) | 0.10 decreased risk for brain edema after a stroke |
| Reference | GRCh38 38.1/141 |
| Chromosome | 18 |
| Position | 26850565 |
| Gene | AQP4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs9951307 |
| dbSNP (classic) | rs9951307 |
| ClinGen | rs9951307 |
| ebi | rs9951307 |
| HLI | rs9951307 |
| Exac | rs9951307 |
| Gnomad | rs9951307 |
| Varsome | rs9951307 |
| LitVar | rs9951307 |
| Map | rs9951307 |
| PheGenI | rs9951307 |
| Biobank | rs9951307 |
| 1000 genomes | rs9951307 |
| hgdp | rs9951307 |
| ensembl | rs9951307 |
| geneview | rs9951307 |
| scholar | rs9951307 |
| rs9951307 | |
| pharmgkb | rs9951307 |
| gwascentral | rs9951307 |
| openSNP | rs9951307 |
| 23andMe | rs9951307 |
| SNPshot | rs9951307 |
| SNPdbe | rs9951307 |
| MSV3d | rs9951307 |
| GWAS Ctlg | rs9951307 |
| GMAF | 0.2957 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs9951307is a SNP in the aquaporin-4 (AQP4) gene; the corresponding protein is the main water channel in the brain and is implicated in the development of brain edema after an ischemic stroke.
A study of 41 patients with middle cerebral artery occlusion with and without severe brain edema found that rs9951307 was associated with severe brain edema (dominant model, p=0.01; OR, 0.10, CI: 0.02 to 0.49 for the protective (G) allele).[PMID 18309154]
