rs9642880

bladder cancer

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	2	Slightly lower risk of Bladder Cancer.
(G;T)	1.5	1.2x increased bladder cancer risk
(T;T)	2	1.5x increased bladder cancer risk

Reference

GRCh38 38.1/142

Chromosome

8

Position

127705823

Gene

CASC11

is a	snp
is	mentioned by
dbSNP	rs9642880
dbSNP (classic)	rs9642880
ClinGen	rs9642880
ebi	rs9642880
HLI	rs9642880
Exac	rs9642880
Gnomad	rs9642880
Varsome	rs9642880
LitVar	rs9642880
Map	rs9642880
PheGenI	rs9642880
Biobank	rs9642880
1000 genomes	rs9642880
hgdp	rs9642880
ensembl	rs9642880
geneview	rs9642880
scholar	rs9642880
google	rs9642880
pharmgkb	rs9642880
gwascentral	rs9642880
openSNP	rs9642880
23andMe	rs9642880
SNPshot	rs9642880
SNPdbe	rs9642880
MSV3d	rs9642880
GWAS Ctlg	rs9642880

GMAF

0.4963

Max Magnitude

2

?	(G;G) (G;T) (T;T)	28

rs9642880 is a SNP located in chromosome region 8q24, a region that has been linked to prostate, breast, and colon cancer.

A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs9642880(T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer.10.1038/ng.229

Another study in Chinese populations found similar results in regard to bladder cancer. [PMID 19369583]

[PMID 18794855] rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers.

[PMID 19801959] In contrast to GSTM1 SNPs, the rs9642880(T) was only associated with increased risk for bladder cancer in cases not selected based on exposure to bladder carcinogens such as aromatic amines and polycyclic aromatic hydrocarbons, based on an analysis of 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens was documented.

GWAS
SNP	rs9642880
PubMedID	[PMID 18794855]
Condition	Urinary bladder cancer
Gene	MYC, BC042052
Risk Allele	T
pValue	9.00E-012
OR	1.22
95% CI	1.15-1.29

OMIM	109800
Desc	BLADDER CANCER
Variant
Related	also

GWAS snp
PMID	[PMID 20348956]
Trait	Urinary bladder cancer
Title	A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
Risk Allele	T
P-val	7E-12
Odds Ratio	1.21 [1.15-1.28]

[PMID 21051319] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study

GWAS snp
PMID	[PMID 20972438]
Trait
Title	A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Risk Allele	T
P-val	2E-18
Odds Ratio	1.2100 [1.16-1.27]

[PMID 20065031] Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.

[PMID 22177160] Genetic variability in 8q24 confers susceptibility to urothelial carcinoma of the upper urinary tract and is linked with patterns of disease aggressiveness at diagnosis.

[PMID 23053209] Genetic polymorphisms on 8q24.1 and 4p16.3 are not linked with urothelial carcinoma of the bladder in contrast to their association with aggressive upper urinary tract tumours

[PMID 22994575] Bladder cancer survival in a former industrial area in Saxony-Anhalt, Germany

[PMID 23284801] Distinct SNP combinations confer susceptibility to urinary bladder cancer in smokers and non-smokers

GWAS snp
PMID	[PMID 24163127]
Trait	Bladder cancer
Title	Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Risk Allele	T
P-val	4E-38
Odds Ratio	1.24 [1.20-1.28]

[PMID 26884936] The association between rs9642880 gene polymorphism and bladder cancer risk: a meta-analysis.

[PMID 30914434] Interactions of PVT1 and CASC11 on Prostate Cancer Risk in African Americans.

[PMID 32384449] Genetic risk scores based on risk-associated single nucleotide polymorphisms can reveal inherited risk of bladder cancer in Chinese population.