| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
2x increased risk for gallstones in males
|
| (C;T)
|
|
possible lower cholesterol, increased gallstone risk in males
|
| (T;T)
|
|
normal
|
rs9514089 is a SNP in the solute carrier family 10 (sodium/bile acid cotransporter family), member 2 SLC10A2 gene.
A pooled analysis comprising 255 controls and 240 gallstone carriers indicated increased risk for cholelithiasis among rs9514089(G;G) homozgyotes, with an odds ratio of 2.99 (p=0.01). This was also associated with lower cholesterol levels.[PMID 19823678
]
[PMID 22093174] Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts
]
