rs9298506

plus

Geno	Mag	Summary
(A;A)	0	~1.46x increased risk of aneurysm
(A;G)	0	~1.21x increased risk of aneurysm
(G;G)	0	Normal risk of aneurysm

Reference

GRCh38 38.1/141

Chromosome

8

Position

54524964

Gene

RP1

is a	snp
is	mentioned by
dbSNP	rs9298506
dbSNP (classic)	rs9298506
ClinGen	rs9298506
ebi	rs9298506
HLI	rs9298506
Exac	rs9298506
Gnomad	rs9298506
Varsome	rs9298506
LitVar	rs9298506
Map	rs9298506
PheGenI	rs9298506
Biobank	rs9298506
1000 genomes	rs9298506
hgdp	rs9298506
ensembl	rs9298506
geneview	rs9298506
scholar	rs9298506
google	rs9298506
pharmgkb	rs9298506
gwascentral	rs9298506
openSNP	rs9298506
23andMe	rs9298506
SNPshot	rs9298506
SNPdbe	rs9298506
MSV3d	rs9298506
GWAS Ctlg	rs9298506

GMAF

0.1878

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

A meta-analysis in 2013 for more than 116,000 individuals showed OR 1.21; 95% CI 1.15–1.27. [PMID 23733552 ] Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals. - 2013

Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the rs9298506(A) allele has been associated with higher risk of aneurysm, with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). [PMID 20364137 ]

GWAS snp
PMID	[PMID 18997786 ]
Trait	Intracranial aneurysm
Title	Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele	A
P-val	2E-9
Odds Ratio	1.35 [1.22-1.49]

OMIM	612587
Desc
Variant
Related	also

[PMID 17903302 ] Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.

Brain Aneurysm

[PMID 23733552 ] Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.

[PMID 25053769 ] Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain