| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
2x increased risk for neuroblastoma
|
| (A;C)
|
|
possible increased risk for neuroblastoma
|
| (C;C)
|
0
|
normal
|
SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs9295536(A;A) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.93, CI: 1.55 to 2.40, p=8 x 10-8). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival.[PMID 18463370
]
For more information on this cluster of SNPs, see rs6939340.
[PMID 19412175] Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.
| GWAS snp
|
| PMID
|
[PMID 22941191]
|
| Trait
|
Neuroblastoma
|
| Title
|
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
|
| Risk Allele
|
A
|
| P-val
|
8E-16
|
| Odds Ratio
|
1.36 [NR]
|
]
