rs7900194
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | CYP2C9*8 homozygote | |
| (A;G) | carrier of one CYP2C9*8 allele | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 94942309 |
| Gene | CYP2C9 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7900194 |
| dbSNP (classic) | rs7900194 |
| ClinGen | rs7900194 |
| ebi | rs7900194 |
| HLI | rs7900194 |
| Exac | rs7900194 |
| Gnomad | rs7900194 |
| Varsome | rs7900194 |
| LitVar | rs7900194 |
| Map | rs7900194 |
| PheGenI | rs7900194 |
| Biobank | rs7900194 |
| 1000 genomes | rs7900194 |
| hgdp | rs7900194 |
| ensembl | rs7900194 |
| geneview | rs7900194 |
| scholar | rs7900194 |
| rs7900194 | |
| pharmgkb | rs7900194 |
| gwascentral | rs7900194 |
| openSNP | rs7900194 |
| 23andMe | rs7900194 |
| SNPshot | rs7900194 |
| SNPdbe | rs7900194 |
| MSV3d | rs7900194 |
| GWAS Ctlg | rs7900194 |
| GMAF | 0.0124 |
| Max Magnitude | 0 |
rs7900194, also known as 449G>A, 3627G>A or R150H, is a SNP in the CYP2C9 gene.
The rs7900194(A) allele defines the CYP2C9*8 variant, which has decreased activity.
According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.
[PMID 19663669
] CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosing.
| ClinVar | |
|---|---|
| Risk | Rs7900194(A;A) rs7900194(T;T) |
| Alt | Rs7900194(A;A) rs7900194(T;T) |
| Reference | Rs7900194(G;G) |
| Significance | Drug-response |
| Disease | warfarin response - Dosage |
| Variation | info |
| Gene | CYP2C9 |
| CLNDBN | warfarin response - Dosage, Toxicity/ADR |
| Reversed | 0 |
| HGVS | NC_000010.10:g.96702066G>A |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211130.1, |
