rs7775228 is one of three HLA region SNPs used to tag the DQ2.2 haplotype in gs221. [PMID 18509540
]
rs7775228(T) was found to be associated with increased risk for osteoarthritis among Japanese, but not Europeans, with an odds ratio of 1.34 (CI: 1.21-1.49, combined p = 2.43×10e?8). This SNP is also in linkage disequilibrium with rs10947262, which was found to be associated in multiple populations with osteoarthritis.[PMID 20305777]
23andMe reports that the C allele at rs7775228 is associated with hay fever (allergic rhinitis and allergy to grass pollen. [PMID 22036096]
[PMID 19950296] Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1
| GWAS snp
|
| PMID
|
[PMID 21804548]
|
| Trait
|
|
| Title
|
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
|
| Risk Allele
|
A
|
| P-val
|
5E-15
|
| Odds Ratio
|
1.1700 [1.12-1.21]
|
[PMID 19458352] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
]
