rs760805

plus

Geno	Mag	Summary
(A;A)		2x increased risk for bladder cancer
(A;T)		increased risk for bladder cancer if part of risk haplotype
(T;T)		normal

Reference

GRCh38 38.1/141

Chromosome

1

Position

24925432

Gene	LOC107984932, RUNX3

is a	snp
is	mentioned by
dbSNP	rs760805
dbSNP (classic)	rs760805
ClinGen	rs760805
ebi	rs760805
HLI	rs760805
Exac	rs760805
Gnomad	rs760805
Varsome	rs760805
LitVar	rs760805
Map	rs760805
PheGenI	rs760805
Biobank	rs760805
1000 genomes	rs760805
hgdp	rs760805
ensembl	rs760805
geneview	rs760805
scholar	rs760805
google	rs760805
pharmgkb	rs760805
gwascentral	rs760805
openSNP	rs760805
23andMe	rs760805
SNPshot	rs760805
SNPdbe	rs760805
MSV3d	rs760805
GWAS Ctlg	rs760805

GMAF

0.4229

Max Magnitude

0

?

(A;A) (A;T) (T;T)

28

rs760805, a SNP in the RUNX3 gene, has been reported to be the most significantly associated with risk for bladder cancer of several SNPs in this gene, based on a study of 368 Chinese patients. The adjusted odds ratio for the rs760805(A;A) genotype is 1.97 (CI: 1.44-2.69).[PMID 18684727]

Further investigation of this region in this same study indicated that 4 other SNPs in the RUNX3 gene, as well as smoking, are associated with increased risk for bladder cancer. In particular, 2 haplotypes, both containing the rs760805(A) allele, were associated with 2-3x increased risk. An individual carrying the risk forms of all 5 RUNX3 SNPs and also smoking had on average an odds ratio for bladder cancer that was 6.37 fold higher than average (CI: 4.57-8.87, p = 7.03 x 10(-28)).[PMID 18684727]

[PMID 19552756] Genetic variants in the Runt-related transcription factor 3 gene contribute to gastric cancer risk in a Chinese population

[PMID 19728008] Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese