rs743554

minus

Geno	Mag	Summary
(C;C)	0	normal
(C;T)		2x higher ER- breast cancer risk
(T;T)		2x higher ER- breast cancer risk

Reference

GRCh38 38.1/142

Chromosome

17

Position

75758167

Gene	GALK1, ITGB4

is a	snp
is	mentioned by
dbSNP	rs743554
dbSNP (classic)	rs743554
ClinGen	rs743554
ebi	rs743554
HLI	rs743554
Exac	rs743554
Gnomad	rs743554
Varsome	rs743554
LitVar	rs743554
Map	rs743554
PheGenI	rs743554
Biobank	rs743554
1000 genomes	rs743554
hgdp	rs743554
ensembl	rs743554
geneview	rs743554
scholar	rs743554
google	rs743554
pharmgkb	rs743554
gwascentral	rs743554
openSNP	rs743554
23andMe	rs743554
SNPshot	rs743554
SNPdbe	rs743554
MSV3d	rs743554
GWAS Ctlg	rs743554

GMAF

0.1373

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

[PMID 18550570] microRNA 749 Swedish incident breast cancer cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. The strongest association was between the rs743554(T) allele of the ITGB4 gene and estrogen receptor negative (ER-) tumors (odds ratio 2.09, CI: 1.19-3.67) and worse survival compared to the wild type genotype carriers (hazard ratio [HR] 2.11, CI: 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage.

[PMID 19290790 ] MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.