| Geno
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Mag
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Summary
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| (C;C)
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no positive effect of AChE inhibitors for Alzheimer's patients
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| (C;T)
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some positive effect of AChE inhibitors for Alzheimer's patients
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| (T;T)
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largest positive effect of AChE inhibitors for Alzheimer's patients
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rs733722, also known as -5293C>T, is a SNP near the choline acetyltransferase CHAT gene.
A study of 121 Alzheimer's disease patients treated primarily with the acetylcholinesterase (AChE) inhibitors donepezil or galantamine found different rates of mental decline depending on rs733722 genotypes. Individuals of rs733722(C;C) genotype effectively showed declines in cognition over time equivalent to untreated patients, whereas rs733722(C;T) individuals showed less decline, and rs733722(T;T) patients had a negligible decline over the course of the study (~15 months).[PMID 16424819]
An earlier study by these authors found no association between SNPs in this gene and actual risk for Alzheimer's.[PMID 12759818]
[PMID 18072279
] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.
[PMID 18165968] Identification of pharmacogenetic markers in smoking cessation therapy.
] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.
