rs7294

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(G;G)	0	common in clinvar

Make rs7294(A;A)

Make rs7294(A;G)

Reference

GRCh38 38.1/141

Chromosome

16

Position

31091000

Gene	PRSS53, VKORC1

is a	snp
is	mentioned by
dbSNP	rs7294
dbSNP (classic)	rs7294
ClinGen	rs7294
ebi	rs7294
HLI	rs7294
Exac	rs7294
Gnomad	rs7294
Varsome	rs7294
LitVar	rs7294
Map	rs7294
PheGenI	rs7294
Biobank	rs7294
1000 genomes	rs7294
hgdp	rs7294
ensembl	rs7294
geneview	rs7294
scholar	rs7294
google	rs7294
pharmgkb	rs7294
gwascentral	rs7294
openSNP	rs7294
23andMe	rs7294
SNPshot	rs7294
SNPdbe	rs7294
MSV3d	rs7294
GWAS Ctlg	rs7294

Merged from

Rs17880624

GMAF

0.3108

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 19436136] Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status

[PMID 21127708] Genetic Variation of VKORC1 and CYP4F2 Genes Related to Warfarin Maintenance Dose in Patients with Myocardial Infarction

[PMID 21590310] Evaluation of the effects of VKORC1 polymorphisms and haplotypes, CYP2C9 genotypes, and clinical factors on warfarin response in Sudanese patients

[PMID 17048007] Association of warfarin dose with genes involved in its action and metabolism.

[PMID 18252229] Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.

[PMID 18305455] Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

[PMID 18466099] Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

[PMID 18523153] Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

[PMID 18535201] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.

[PMID 18698231] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18752379] Warfarin pharmacogenetics.

[PMID 18855533] VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

[PMID 19226183] Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient.

[PMID 19228618] Estimation of the warfarin dose with clinical and pharmacogenetic data.

[PMID 19955245] Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.

[PMID 20018050] Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.

[PMID 21359226] The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.

[PMID 23208322] Influence of ORM1 polymorphisms on the maintenance stable warfarin dosage

[PMID 23662025] Genetic variation and haplotype structure of the gene Vitamin K epoxide reductase complex, subunit 1 in the Tamilian population

[PMID 23133420] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

ClinVar
Risk	rs7294(A;A)
Alt	rs7294(A;A)
Reference	Rs7294(G;G)
Significance	Drug-response
Disease	phenprocoumon response - Dosage warfarin response - Dosage acenocoumarol response - Dosage Vitamin K-Dependent Clotting Factors
Variation	info
Gene	VKORC1
CLNDBN	phenprocoumon response - Dosage warfarin response - Dosage acenocoumarol response - Dosage Vitamin K-Dependent Clotting Factors
Reversed	1
HGVS	NC_000016.9:g.31102321C>T
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000211189.1, RCV000211278.1, RCV000211362.1, RCV000295118.1,

[PMID 31338002] Association between four microRNA binding site-related polymorphisms and the risk of warfarin-induced bleeding complications.