| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
higher Alzheimer's risk if ApoE4 also present
|
| (A;G)
|
1.8
|
0.70x reduced risk for Alzheimer's risk
|
| (G;G)
|
2
|
0.70x reduced risk for Alzheimer's risk
|
rs7101429 is a SNP in the GRB2-associated binding protein 2 GAB2 gene.
In a study of 4000 DNA samples from ~1300 families affected by Alzheimer's disease, there was a reduced risk (0.70x; p = .002) among carriers of the rs7101429(G) minor allele.[PMID 19204162]
[PMID 19204163
] GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
[PMID 21285854] Association Study of the GAB2 Gene With the Risk of Alzheimer Disease in the Chinese Population
[PMID 17553421] GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
[PMID 22856364] Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins
[PMID 23071633] Mining pure, strict epistatic interactions from high-dimensional datasets: ameliorating the curse of dimensionality.
] GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results.
