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rs705117

From SNPedia

Orientationminus
Stabilizedminus
Make rs705117(A;A)
Make rs705117(A;G)
Make rs705117(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position71742398
GeneGC
is asnp
is mentioned by
dbSNPrs705117
dbSNP (classic)rs705117
ClinGenrs705117
ebirs705117
HLIrs705117
Exacrs705117
Gnomadrs705117
Varsomers705117
LitVarrs705117
Maprs705117
PheGenIrs705117
Biobankrs705117
1000 genomesrs705117
hgdprs705117
ensemblrs705117
geneviewrs705117
scholarrs705117
googlers705117
pharmgkbrs705117
gwascentralrs705117
openSNPrs705117
23andMers705117
SNPshotrs705117
SNPdbers705117
MSV3drs705117
GWAS Ctlgrs705117
GMAF0.4109
Max Magnitude0

A 2014 GWAS of ~1,400 Caucasian men ages 50-70 found that after rs7041, the SNP most significantly associated with fasting serum levels of vitamin D binding protein (VDBP, encoded by the GC gene) is rs705117. The average VDBP levels measured were 6339, 4280, and 2341 nmol/L, for 0, 1, and 2 copies of the rs705117(G) allele.[PMID 24740207OA-icon.png]

? (A;A) (A;G) (G;G) 28


[PMID 23505139] An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population


[PMID 18593774OA-icon.png] Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans.


[PMID 19255064OA-icon.png] Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.


[PMID 19543766OA-icon.png] Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families.


[PMID 22785457] Association of vitamin D-related gene polymorphisms with manifestation of vitamin D deficiency in children.

GWAS snp
PMID [PMID 24740207OA-icon.png]
Trait Serum vitamin D-binding protein levels
Title Genome-wide association study of circulating vitamin D-binding protein.
Risk Allele G
P-val 5E-91
Odds Ratio ####### [1829.00-2224.56] nmol/L decrease