rs6454674
| Orientation | plus |
| Stabilized | plus |
| Make rs6454674(G;G) |
| Make rs6454674(G;T) |
| Make rs6454674(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 88163211 |
| Gene | CNR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6454674 |
| dbSNP (classic) | rs6454674 |
| ClinGen | rs6454674 |
| ebi | rs6454674 |
| HLI | rs6454674 |
| Exac | rs6454674 |
| Gnomad | rs6454674 |
| Varsome | rs6454674 |
| LitVar | rs6454674 |
| Map | rs6454674 |
| PheGenI | rs6454674 |
| Biobank | rs6454674 |
| 1000 genomes | rs6454674 |
| hgdp | rs6454674 |
| ensembl | rs6454674 |
| geneview | rs6454674 |
| scholar | rs6454674 |
| rs6454674 | |
| pharmgkb | rs6454674 |
| gwascentral | rs6454674 |
| openSNP | rs6454674 |
| 23andMe | rs6454674 |
| SNPshot | rs6454674 |
| SNPdbe | rs6454674 |
| MSV3d | rs6454674 |
| GWAS Ctlg | rs6454674 |
| GMAF | 0.3067 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 17509535] risk of the development of substance dependence significantly increased with the number of "G" alleles at rs6454674 and SNP8;T/T genotypes had significant interaction effects (p = .0003 for comorbid DD and AD, .0002 for DD, and .007 for AD). SNP3 and SNP8 together exerted stronger genetic effects on SD than either did individually. The peak delta values among all the markers were seen for SNP3 and SNP8 (rs806368)
[PMID 19052543
] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
rs806377(C) together with rs6454674(G) make up a haplotype associated (p=0.008) with higher risk of ADHD. In addition, the haplotype was more associated (p=0.03) with ADHD in males than in females with the risk haplotype. [PMID 18213623]
[PMID 22085192] Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence
[PMID 16917946] Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.
[PMID 17881126] No association of CNR1 gene variations with susceptibility to schizophrenia.
[PMID 18375449] Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
[PMID 18606954] Cannabinoid receptor 1 gene association with nicotine dependence.
[PMID 19016476] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
[PMID 19335651] Candidate genes for cannabis use disorders: findings, challenges and directions.
[PMID 19443135] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.
[PMID 19886064] The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.
[PMID 20838400] Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?
[PMID 21480765] Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.
[PMID 21790903] Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.
[PMID 24407958] Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
[PMID 23422373] CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.
[PMID 25136364] Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls
