rs6295
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in clinvar |
| Make rs6295(C;C) |
| Make rs6295(C;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 63962738 |
| Gene | HTR1A |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6295 |
| dbSNP (classic) | rs6295 |
| ClinGen | rs6295 |
| ebi | rs6295 |
| HLI | rs6295 |
| Exac | rs6295 |
| Gnomad | rs6295 |
| Varsome | rs6295 |
| LitVar | rs6295 |
| Map | rs6295 |
| PheGenI | rs6295 |
| Biobank | rs6295 |
| 1000 genomes | rs6295 |
| hgdp | rs6295 |
| ensembl | rs6295 |
| geneview | rs6295 |
| scholar | rs6295 |
| rs6295 | |
| pharmgkb | rs6295 |
| gwascentral | rs6295 |
| openSNP | rs6295 |
| 23andMe | rs6295 |
| SNPshot | rs6295 |
| SNPdbe | rs6295 |
| MSV3d | rs6295 |
| GWAS Ctlg | rs6295 |
| GMAF | 0.4789 |
| Max Magnitude | 0 |
[PMID 25412229
] The association between romantic relationship status and 5-HT1A gene in young adults.
[PMID 19358877] Imaging Phenotypes of Major Depressive Disorder: Genetic Correlates
[PMID 19326813] A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
[PMID 19560507] Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder
[PMID 19725031] Significant association between the C(-1019)G functional polymorphism of the HTR(1A) gene and impulsivity
[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
[PMID 20043001] Risk-Taking Behavior in a Gambling Task Associated with Variations in the Tryptophan Hydroxylase 2 Gene: Relevance to Psychiatric Disorders
[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population
[PMID 19730445] Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis
[PMID 19747927] Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
[PMID 20594600] Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis
[PMID 21449006] Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to transcranial magnetic stimulation
[PMID 21619616] Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
[PMID 22232550] Deaf-1 knockout mice display increased 5-HT1A autoreceptor expression and reduced raphe serotonin levels
[PMID 22826341] Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
[PMID 16626484] The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.
[PMID 17192951] HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 18163385] Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.
[PMID 18308786] The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.
[PMID 18387137] 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder.
[PMID 18715570] Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.
[PMID 18848359] The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.
[PMID 19124686] Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.
[PMID 19359258] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
[PMID 19428959] 5-HT(1A) receptor function in major depressive disorder.
[PMID 19829169] SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.
[PMID 19997044] No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
[PMID 20454985] Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents.
[PMID 20638825] The HTR1A and HTR1B receptor genes influence stress-related information processing.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21208417] International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.
[PMID 21621273] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.
[PMID 22064163] Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.
[PMID 22392387] No association between the HTR1A gene and suicidal behavior: a meta-analysis.
[PMID 23192369] Relationship Between Genetic Polymorphisms in the HTR1A Gene and Paranoid Schizophrenia in a Northern Han Chinese Population
[PMID 23269215] Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype - genotype associations in depression
[PMID 23798967] No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy
[PMID 23318131] Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery
[PMID 24158751] The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder
[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants
[PMID 22727709] Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder.
[PMID 22752684] The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.
[PMID 22890315] Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.
[PMID 23036158] The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients.
[PMID 23333373] Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.
[PMID 23375453] Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.
[PMID 23547754] Genetics of serotonin receptors and depression: state of the art.
[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
[PMID 25247748] Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation
[PMID 25990886] Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression
[PMID 24021217] Common selective serotonin reuptake inhibitor side effects in older adults associated with genetic polymorphisms in the serotonin transporter and receptors: data from a randomized controlled trial
[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study
| ClinVar | |
|---|---|
| Risk | rs6295(C;C) |
| Alt | rs6295(C;C) |
| Reference | Rs6295(G;G) |
| Significance | Drug-response |
| Disease | paroxetine response - Efficacy |
| Variation | info |
| Gene | HTR1A |
| CLNDBN | paroxetine response - Efficacy |
| Reversed | 1 |
| HGVS | NC_000005.9:g.63258565C>G |
| CLNSRC | PharmGKB Clinical Annotation PharmGKB |
| CLNACC | RCV000417153.1, |
[PMID 30074224] Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.
[PMID 30694044] Functional interrogation of a depression-related serotonergic SNP, rs6295, using a humanized mouse model.
[PMID 31291234] Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD.
[PMID 32957930] Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis.
