rs6265(A;A)

introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients

Is a	genotype
of	rs6265
Gene	BDNF, BDNF-AS
Chromosome	11
Position	27,658,369
mentioned	by

Magnitude

2.6

Repute

Bad

Geno	Mag	Summary
(A;A)	2.6	introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients
(A;G)	2.6	Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients
(G;G)	0	common/normal

Met/Met (higher risk) variant of the Val66Met SNP in the BDNF gene that codes for brain-derived neurotrophic factor. Met/Met is associated in some (but not all) studies with slightly increased susceptibility to certain mental health disorders such as ADHD and depression.

[PMID 20042999] associated with introversion

This genotype may provide resistance to depression when subjected to repeated defeat blog summary

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]

Wired discusses the research as does 23andMe blog.