rs6265

minus

Geno	Mag	Summary
(A;A)	2.6	introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients
(A;G)	2.6	Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients
(G;G)	0	common/normal

Reference

GRCh38 38.1/142

Chromosome

11

Position

27658369

Gene	BDNF, BDNF-AS

is a	snp
is	mentioned by
dbSNP	rs6265
dbSNP (classic)	rs6265
ClinGen	rs6265
ebi	rs6265
HLI	rs6265
Exac	rs6265
Gnomad	rs6265
Varsome	rs6265
LitVar	rs6265
Map	rs6265
PheGenI	rs6265
Biobank	rs6265
1000 genomes	rs6265
hgdp	rs6265
ensembl	rs6265
geneview	rs6265
scholar	rs6265
google	rs6265
pharmgkb	rs6265
gwascentral	rs6265
openSNP	rs6265
23andMe	rs6265
SNPshot	rs6265
SNPdbe	rs6265
MSV3d	rs6265
GWAS Ctlg	rs6265

GMAF

0.2287

Max Magnitude

2.6

?

(A;A) (A;G) (G;G)

28

rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met.

The A allele may also be protective against depression when subjected to repeated defeat [PMID 17956738] g2b2mh blog

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020 ]

A 2017 study of 1,000 Alzheimer's disease patients, a third of whom were rs6265(A) carriers, concluded that over the ~7 year study such carriers lost memory and thinking skills somewhat more rapidly than non-carriers.10.1212/WNL.0000000000003980

Wired discusses the research as does 23andMe blog.

[PMID 25288136 ] Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. [PMID 20042999 ] Met/A allele associated with introversion

[PMID 17293537 ] Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265, as well as the diplotypes of rs6265, rs11030104, and rs2049045.

[PMID 18600033] Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour

[PMID 19209189 ] In 2 studies of British women, rs6265(A;A) women had a lower body mass index than rs6265(G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.

[PMID 19388013 ] BDNF, relative preference, and reward circuitry responses to emotional communication

GWAS snp
PMID	[PMID 19079260]
Trait	Body mass index
Title	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Risk Allele	G
P-val	5E-10
Odds Ratio	4.58 [3.07-6.09] % SD

[PMID 19461660] No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

[PMID 19530966] Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis

[PMID 19603419] Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations

[PMID 20943059] Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms

[PMID 15940292] A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

[PMID 18286632] Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder

OMIM	113505
Desc	BRAIN-DERIVED NEUROTROPHIC FACTOR; BDNF
Variant
Related	also

[PMID 19699537] Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent

[PMID 19925205] Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging

[PMID 20033742] Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population

[PMID 19895626] The effect of BDNF gene variants on asthma in German children

[PMID 20087404 ] Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study

[PMID 20147969] Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension

[PMID 20418890 ] Genome-wide meta-analyses identify multiple loci associated with smoking behavior

[PMID 20682308] The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder

[PMID 20456319] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

[PMID 20702703 ] The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks

[PMID 20959432] BDNF and CGRP interaction: Implications in migraine susceptibility

[PMID 20966902 ] Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder

[PMID 20843981 ] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children

[PMID 21300947] The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease

OMIM	113505
Desc
Variant	0002
Related	also

[PMID 21723144] Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore

[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area

[PMID 21527513] Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity

[PMID 21889574] Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder

[PMID 21980924 ] BDNF Val66Met and Cognition: All, None, or Some? A Meta-Analysis of the Genetic Association

[PMID 22033217] Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women

[PMID 22085476] Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

[PMID 22127997] No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese

[PMID 22173577] Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans

[PMID 22188054 ] Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury

[PMID 22194877 ] Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding

[PMID 21641949] Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population

[PMID 21880305] The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response

[PMID 22548711] Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population

[PMID 22719849 ] Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

[PMID 22766130 ] BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis

ClinVar
Risk	Rs6265(A;A)
Alt	Rs6265(A;A)
Reference	Rs6265(G;G)
Significance	Other
Disease	Memory impairment Obsessive-compulsive disorder Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder Parkinson disease not specified
Variation	info
Gene	BDNF-AS BDNF
CLNDBN	Memory impairment, susceptibility to Obsessive-compulsive disorder, protection against Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder, susceptibility to Parkinson disease not specified
Reversed	1
HGVS	NC_000011.9:g.27679916C>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000019267.3, RCV000019268.2, RCV000019269.3, RCV000019270.3, RCV000019271.3, RCV000019272.3, RCV000155463.2,

[PMID 12836135 ] Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.

[PMID 15457498] Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.

[PMID 16005437] Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.

[PMID 16497333] No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults.

[PMID 16631352] No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population.

[PMID 16741941] Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.

[PMID 16962786] Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.

[PMID 17096834 ] No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.

[PMID 17135278 ] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

[PMID 17196936] Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis.

[PMID 17212826 ] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.

[PMID 17219016] No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.

[PMID 17417060] Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.

[PMID 17483451 ] Gene-gene interaction associated with neural reward sensitivity.

[PMID 17503330 ] A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.

[PMID 17602759] Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis.

[PMID 17632285 ] The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.

[PMID 17656372] Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.

[PMID 17657167] Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.

[PMID 17894414 ] BDNF Val66Met variant and age of onset in schizophrenia.

[PMID 17918236] Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder.

[PMID 18205169] Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.

[PMID 18478177] Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine.

[PMID 18534558 ] Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.

[PMID 18565990 ] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.

[PMID 18698231 ] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18704161 ] Genetic variation in an individual human exome.

[PMID 18776599 ] Susceptibility genes for gentamicin-induced vestibular dysfunction.

[PMID 18813964 ] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

[PMID 18830724 ] Assessment of Alzheimer's disease case-control associations using family-based methods.

[PMID 18852698] Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.

[PMID 18957941 ] Genome-wide association scan for five major dimensions of personality.

[PMID 19018231 ] Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

[PMID 19018715] Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.

[PMID 19236730] Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response.

[PMID 19258022 ] Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.

[PMID 19295238] Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

[PMID 19330778] Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population.

[PMID 19336781 ] Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.

[PMID 19359258 ] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

[PMID 19412541 ] Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.

[PMID 19424874] Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.

[PMID 19478790 ] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 19582215 ] Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray.

[PMID 19582565 ] Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.

[PMID 19721723 ] Brain-derived neurotrophic factor: role in depression and suicide.

[PMID 19721846 ] Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants.

[PMID 19844571 ] Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.

[PMID 19940176 ] Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.

[PMID 19953912] [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].

[PMID 20004415] Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene.

[PMID 20008943 ] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 20014955] Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression.

[PMID 20016225] Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients.

[PMID 20127379 ] From monogenic to polygenic obesity: recent advances.

[PMID 20172611] Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder.

[PMID 20191112 ] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.

[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.

[PMID 20400928 ] Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.

[PMID 20426150] Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture.

[PMID 20478698] Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study.

[PMID 20482942] Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.

[PMID 20493546 ] BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.

[PMID 20574532 ] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

[PMID 20712903 ] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 21037213 ] Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.

[PMID 21049304 ] Influence of candidate genes on attention problems in children: a longitudinal study.

[PMID 21097659] Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects.

[PMID 21103954] Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population.

[PMID 21167606] The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities.

[PMID 21172166 ] Pharmacogenetics of antidepressant response.

[PMID 21215389] The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.

[PMID 21305693] Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction.

[PMID 21458533] Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence.

[PMID 21491204] Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF.

[PMID 21509595 ] Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.

[PMID 21577214] BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.

[PMID 21640793] Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients.

[PMID 21695421 ] Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?

[PMID 21745335 ] 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.

[PMID 21875455] The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.

[PMID 21898033 ] Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.

[PMID 21931317 ] BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

[PMID 21956459] Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment.

[PMID 21996278] Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

[PMID 22008662] The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior.

[PMID 22094229] Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.

[PMID 22179955 ] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

[PMID 22585743] Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.

[PMID 22609366] Neurotrophic Tyrosine Kinase Polymorphism Impacts White Matter Connections in Patients with Major Depressive Disorder.

[PMID 22610920 ] The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.

[PMID 22642961] The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.

[PMID 22965830] No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression

[PMID 22615781 ] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study

[PMID 23170235 ] BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humans

[PMID 23269345] BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects

[PMID 23341118] Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume

[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia

[PMID 23482723 ] Association between the BDNF Val66Met Polymorphism and Chronicity of Depression

[PMID 23487199] BDNF val66met Polymorphism Is Associated With Age at Onset and Intensity of Symptoms of Paranoid Schizophrenia in a Polish Population

[PMID 23628854 ] FTO predicts weight regain in the Look AHEAD clinical trial

[PMID 23712400 ] SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans

[PMID 23923080 ] Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia

[PMID 23424664 ] Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children

[PMID 23999029] Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder

[PMID 23433505 ] Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia

[PMID 24198753 ] Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking

[PMID 24269186] An obesity genetic risk score is associated with metabolic syndrome in Chinese children

[PMID 24399714] BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample

[PMID 24567226] Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols

[PMID 23408508 ] Obesity-susceptibility loci and the tails of the pediatric BMI distribution

[PMID 22813992] Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis.

[PMID 22844024 ] Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.

[PMID 22846907] Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.

[PMID 22989210 ] Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.

[PMID 23023098] Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes.

[PMID 23062292 ] The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems.

[PMID 23137999 ] The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.

[PMID 23184535 ] No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.

[PMID 23303061 ] Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment.

[PMID 23461616] Association between brain-derived neurothropic factor variants and asthma in Chinese Han children.

[PMID 23643991] Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 23832605] Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.

[PMID 24863266] Val66Met polymorphism in the BDNF gene in children with bronchial asthma

[PMID 24993285] BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia

[PMID 25044977 ] BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields

[PMID 25052186] Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris

[PMID 25324022] Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response

[PMID 25383981 ] Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea

[PMID 25492288] [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]

[PMID 25649076] A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis

[PMID 25650137] BDNF Val66Met and reward-related brain function in adolescents: Role for early alcohol consumption

[PMID 25660313] Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence

[PMID 25670953 ] Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis

[PMID 25681004] Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis

[PMID 25762803 ] Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

[PMID 24461776] No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia

[PMID 25950609] Association Between BDNF Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

[PMID 25956254] BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

[PMID 24733169 ] Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis

[PMID 26115627] Single nucleotide polymorphisms in the BDNF gene and suicide in the Slovenian sample

[PMID 26117067] BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls

[PMID 26175754 ] DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women

[PMID 26326364] The BDNF Val66Met polymorphism is associated with improved performance on a visual-auditory working memory task in varsity athletes

[PMID 26401760] BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence

[PMID 26432032 ] Interaction between BDNF rs6265 Met allele and low family cohesion is associated with smaller left hippocampal volume in pediatric bipolar disorder

[PMID 26445699 ] Genetic association of the transcription of neuroplasticity-related genes and variation in stress-coping style

[PMID 26739449 ] Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.

[PMID 26889735 ] BDNF rs6265 methylation and genotype interact on risk for schizophrenia.

[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.

[PMID 27647760] The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese population.

[PMID 28387675] DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study.

[PMID 28413930 ] Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.

[PMID 28498887 ] Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study.

[PMID 28755387 ] BDNF Genotype is Associated with Hippocampal Volume in Mild Traumatic Brain Injury.

[PMID 29052254] Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.

[PMID 29191473 ] Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease.

[PMID 30375508 ] Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.

[PMID 30519954] BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm.

[PMID 31132388] Investigating the contribution of NPSR1, IL-6 and BDNF polymorphisms to depressive and anxiety symptoms in hemodialysis patients.

[PMID 30129980] The association between polymorphism of the BDNF gene and cigarette smoking in the Iranian population.

[PMID 31787925 ] BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.

[PMID 32351633 ] An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism.

[PMID 32776402] Role of rs6265 BDNF polymorphisms and post-stroke dysphagia recovery-A prospective cohort study.

[PMID 33007373] Differential promoter methylation and G-712A polymorphism of brain-derived neurotrophic factor in post-traumatic stress disorder patients of Li and Han populations in Hainan province.

[PMID 33384622 ] BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications.

[PMID 33499851 ] Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.

[PMID 31504225 ] Interaction Between Physical Activity and Genes Related to Neurotrophin Signaling in Late-Life Cognitive Performance: The Cache County Study.