rs6123837

Orientation

plus

Stabilized

plus

Make rs6123837(A;A)

Make rs6123837(A;G)

Make rs6123837(G;G)

Reference

GRCh38 38.1/141

Chromosome

20

Position

58890516

Gene	GNAS, LOC101927932

is a	snp
is	mentioned by
dbSNP	rs6123837
dbSNP (classic)	rs6123837
ClinGen	rs6123837
ebi	rs6123837
HLI	rs6123837
Exac	rs6123837
Gnomad	rs6123837
Varsome	rs6123837
LitVar	rs6123837
Map	rs6123837
PheGenI	rs6123837
Biobank	rs6123837
1000 genomes	rs6123837
hgdp	rs6123837
ensembl	rs6123837
geneview	rs6123837
scholar	rs6123837
google	rs6123837
pharmgkb	rs6123837
gwascentral	rs6123837
openSNP	rs6123837
23andMe	rs6123837
SNPshot	rs6123837
SNPdbe	rs6123837
MSV3d	rs6123837
GWAS Ctlg	rs6123837

GMAF

0.3779

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

rs6123837 ( G(-1211)A ) is a SNP within GNAS (GNAS complex locus - encoding the Gs alpha subunit).

[PMID 18192900] among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...

• those with GG genotypes lost significantly more weight compared to A allele carriers
  
• sibutramine was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure

[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.

[PMID 23065660] GNAS A-1121G variant is associated with improved diastolic dysfunction in response to exercise training in heart failure patients.