| Geno
|
Mag
|
Summary
|
| (T;T)
|
|
most common genotype, lower testosterone
|
[PMID 21998597
] "Genetic determinants of serum testosterone concentrations in men" - The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p?=?5.6×10(-16)). The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505.
| GWAS snp
|
| PMID
|
[PMID 22936694]
|
| Trait
|
Androgen levels
|
| Title
|
Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.
|
| Risk Allele
|
G
|
| P-val
|
2E-8
|
| Odds Ratio
|
.09 [0.060-0.122] unit increase
|
[PMID 23258625] Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality.
[PMID 26602056] The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone and late-onset hypogonadism, but the rs10822184 SNP is associated with overweight and obesity in a Chinese Han population: a case-control study
] "Genetic determinants of serum testosterone concentrations in men" - The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p?=?5.6×10(-16)). The mean serum testosterone and calculated free testosterone but not SHBG concentrations were lower in men with T genotype than in those with C genotype for rs5934505.
