rs58597806
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | normal |
| (G;T) | 1.8 | likely reduced UGT1A9 glucuronidation |
| (T;T) | 2 | likely reduced UGT1A9 glucuronidation |
| Make rs58597806(A;A) |
| Make rs58597806(A;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 233672700 |
| Gene | UGT1A8, UGT1A9, UGT1A10 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs58597806 |
| dbSNP (classic) | rs58597806 |
| ClinGen | rs58597806 |
| ebi | rs58597806 |
| HLI | rs58597806 |
| Exac | rs58597806 |
| Gnomad | rs58597806 |
| Varsome | rs58597806 |
| LitVar | rs58597806 |
| Map | rs58597806 |
| PheGenI | rs58597806 |
| Biobank | rs58597806 |
| 1000 genomes | rs58597806 |
| hgdp | rs58597806 |
| ensembl | rs58597806 |
| geneview | rs58597806 |
| scholar | rs58597806 |
| rs58597806 | |
| pharmgkb | rs58597806 |
| gwascentral | rs58597806 |
| openSNP | rs58597806 |
| 23andMe | rs58597806 |
| SNPshot | rs58597806 |
| SNPdbe | rs58597806 |
| MSV3d | rs58597806 |
| GWAS Ctlg | rs58597806 |
| Max Magnitude | 2 |
rs58597806 (Asp256Asn/D256N) is a SNP within UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9).
[PMID 18816295] reduced propofol glucuronidation - considerably lowered glucuronidation of mycophenolic acid, 1-naphthol, and naringenin. may be at risk adverse effects w/ propofol and other UGT1A9 substrate administration
[PMID 12730278] essentially non-functional with regard to SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronidation, an active metabolite of irinotecan
