rs5361
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal risk |
| (A;C) | normal risk | |
| (C;C) | 2.5 | 4x increased risk for recurrent venous thromboembolism. |
| Reference | GRCh38 38.1/142 |
| Chromosome | 1 |
| Position | 169731919 |
| Gene | SELE |
| is a | snp |
| is | mentioned by |
| dbSNP | rs5361 |
| dbSNP (classic) | rs5361 |
| ClinGen | rs5361 |
| ebi | rs5361 |
| HLI | rs5361 |
| Exac | rs5361 |
| Gnomad | rs5361 |
| Varsome | rs5361 |
| LitVar | rs5361 |
| Map | rs5361 |
| PheGenI | rs5361 |
| Biobank | rs5361 |
| 1000 genomes | rs5361 |
| hgdp | rs5361 |
| ensembl | rs5361 |
| geneview | rs5361 |
| scholar | rs5361 |
| rs5361 | |
| pharmgkb | rs5361 |
| gwascentral | rs5361 |
| openSNP | rs5361 |
| 23andMe | rs5361 |
| SNPshot | rs5361 |
| SNPdbe | rs5361 |
| MSV3d | rs5361 |
| GWAS Ctlg | rs5361 |
| GMAF | 0.0551 |
| Max Magnitude | 2.5 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
The rs5361 Ser128Arg variation in this gene, known as E-selectin, is linked to several thrombotic disorders.
rs5361(C;C) homozygous carriers of the Ser128Arg allele are at a 4X higher risk for recurrent venous thromboembolism (VTE); heterozygous carriers are not at increased risk. [PMID 16908800].
[PMID 22589243] Association of E-selectin gene polymorphisms with ischemic stroke in a Chinese Han population
[PMID 15726497
] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 20622166] Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
[PMID 22116284] A two-step genetic study on quantitative precursors of coronary artery disease in a homogeneous Indian population: case-control association discovery and validation by transmission-disequilibrium test.
[PMID 22388798] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
[PMID 22414298] Lack of an association between E-selectin gene polymorphisms and risk of Kawasaki disease.
[PMID 21780194] E-selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population.
[PMID 23274712] Genetic polymorphisms and the risk of myocardial infarction in patients under 45 years of age.
[PMID 23533563] Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.
[PMID 23772946] Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis.
[PMID 25091233] Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia
