| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
normal risk
|
| (C;G)
|
|
1.19x risk for hypertension
|
| (G;G)
|
|
>1.19x risk for hypertension
|
rs5335, a SNP in the EDNRA gene, has been associated with a (slightly) increased risk for hypertension, based on a study of ~1400 Caucasians. The odds ratio per (G) allele is 1.19 (CI: 1.00-1.41, p=0.05).[PMID 18172451]
[PMID 20028935
] EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates and cystic fibrosis pulmonary disease severity
[PMID 20964792] A role for endothelin receptor type A in migraine without aura susceptibility? A study in Portuguese patients.
[PMID 23206929] Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population
[PMID 26178354] [Association between genetic polymorphisms of EDNRA gene and high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau]
[PMID 28323184] Associations of endothelin polymorphisms and aneurysm size at the time of rupture.
[PMID 29849817] Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population.
] EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates and cystic fibrosis pulmonary disease severity
