rs4585

plus

Geno	Mag	Summary
(G;G)	2	slightly higher (1.35x) odds of good metformin response in type 2 diabetics
(G;T)	2	average response to metformin in type 2 diabetics
(T;T)	1.5	slightly poorer (0.75x) response to metformin in type 2 diabetics

Reference

GRCh38 38.1/141

Chromosome

11

Position

108368901

Gene	ATM, C11orf65

is a	snp
is	mentioned by
dbSNP	rs4585
dbSNP (classic)	rs4585
ClinGen	rs4585
ebi	rs4585
HLI	rs4585
Exac	rs4585
Gnomad	rs4585
Varsome	rs4585
LitVar	rs4585
Map	rs4585
PheGenI	rs4585
Biobank	rs4585
1000 genomes	rs4585
hgdp	rs4585
ensembl	rs4585
geneview	rs4585
scholar	rs4585
google	rs4585
pharmgkb	rs4585
gwascentral	rs4585
openSNP	rs4585
23andMe	rs4585
SNPshot	rs4585
SNPdbe	rs4585
MSV3d	rs4585
GWAS Ctlg	rs4585

GMAF

0.4793

Max Magnitude

2

rs4585 has been found to modify the metformin response in patients with type 2 diabetes.[PMID 21186350 ]

?

(G;G) (G;T) (T;T)

28

[PMID 21058196] Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk

Metformin Response

[PMID 25196645] Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma

[PMID 25759145] ATM Gene Single-Nucleotide Polymorphisms Predict Regimen-Related Gastrointestinal Toxicity in Patients Allografted after Reduced Conditionings

[PMID 28521290] MiR-2964a-5p binding site SNP regulates ATM expression contributing to age-related cataract risk.

ClinVar
Risk	Rs4585(T;T)
Alt	Rs4585(T;T)
Reference	Rs4585(G;G)
Significance	Non-pathogenic
Disease	Ataxia-telangiectasia syndrome
Variation	info
Gene	C11orf65 ATM
CLNDBN	Ataxia-telangiectasia syndrome
Reversed	0
HGVS	NC_000011.9:g.108239628G>T
CLNSRC
CLNACC	RCV000274160.1,

[PMID 29156695 ] MiR-2964a-5p binding site SNP regulates ATM expression contributing to age-related cataract risk.