rs3818361
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.1 | 1.15x increased risk for late-onset Alzheimer's |
| (T;T) | 1.2 | 1.2x increased risk for late-onset Alzheimer's |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 207611623 |
| Gene | CR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3818361 |
| dbSNP (classic) | rs3818361 |
| ClinGen | rs3818361 |
| ebi | rs3818361 |
| HLI | rs3818361 |
| Exac | rs3818361 |
| Gnomad | rs3818361 |
| Varsome | rs3818361 |
| LitVar | rs3818361 |
| Map | rs3818361 |
| PheGenI | rs3818361 |
| Biobank | rs3818361 |
| 1000 genomes | rs3818361 |
| hgdp | rs3818361 |
| ensembl | rs3818361 |
| geneview | rs3818361 |
| scholar | rs3818361 |
| rs3818361 | |
| pharmgkb | rs3818361 |
| gwascentral | rs3818361 |
| openSNP | rs3818361 |
| 23andMe | rs3818361 |
| SNPshot | rs3818361 |
| SNPdbe | rs3818361 |
| MSV3d | rs3818361 |
| GWAS Ctlg | rs3818361 |
| GMAF | 0.2691 |
| Max Magnitude | 1.2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs3818361 is a SNP associated with the complement component (3b/4b) receptor 1 CR1 gene.
[PMID 20554627
] The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls). The odds ratio for rs3818361(T) allele was 1.15 (note the p value was 0.014).
[PMID 20558149] Complement receptor 1 polymorphisms and risk of late onset Alzheimer's disease
[PMID 20697030] Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes
[PMID 21321396] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
| GWAS snp | |
|---|---|
| PMID | [PMID 21460840]
|
| Trait | |
| Title | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease |
| Risk Allele | |
| P-val | 4E-14 |
| Odds Ratio | 1.1800 [1.13-1.24] |
[PMID 19734902] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
[PMID 21379329] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
[PMID 21390209] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
[PMID 22244847] Alzheimer's disease risk factor complement receptor 1 is associated with depression.
[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
[PMID 22430674] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
[PMID 23022416] Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype.
[PMID 24998857] CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease
[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.
[PMID 28316001] Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance.
