rs33949390

plus

Geno	Mag	Summary
(C;C)		3.3x increased risk for Parkinson's disease
(C;G)		3.3x increased risk for Parkinson's disease
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

12

Position

40320043

Gene

LRRK2

is a	snp
is	mentioned by
dbSNP	rs33949390
dbSNP (classic)	rs33949390
ClinGen	rs33949390
ebi	rs33949390
HLI	rs33949390
Exac	rs33949390
Gnomad	rs33949390
Varsome	rs33949390
LitVar	rs33949390
Map	rs33949390
PheGenI	rs33949390
Biobank	rs33949390
1000 genomes	rs33949390
hgdp	rs33949390
ensembl	rs33949390
geneview	rs33949390
scholar	rs33949390
google	rs33949390
pharmgkb	rs33949390
gwascentral	rs33949390
openSNP	rs33949390
23andMe	rs33949390
SNPshot	rs33949390
SNPdbe	rs33949390
MSV3d	rs33949390
GWAS Ctlg	rs33949390

GMAF

0.005051

Max Magnitude

0

Also known as R1628P, rs33949390 is a SNP in the LRRK2 gene.

A study of Chinese patients with Parkinson's disease concluded that in this population, after adjustments were made for age, age of onset, and gender, rs33949390(C) carriers were 3.3x more likely to develop the disease than noncarriers (CI: 1.4- 7.9, p = 0.007).[PMID 18781329]

OMIM	609007
Desc	LEUCINE-RICH REPEAT KINASE 2; LRRK2
Variant
Related	also

[PMID 19854095] The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population

[PMID 20186690] Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.

ClinVar
Risk	rs33949390(A;A) Rs33949390(C;C) rs33949390(T;T)
Alt	rs33949390(A;A) Rs33949390(C;C) rs33949390(T;T)
Reference	Rs33949390(G;G)
Significance	Other
Disease	Parkinson disease 8
Variation	info
Gene	LRRK2
CLNDBN	Parkinson disease 8, autosomal dominant
Reversed	0
HGVS	NC_000012.11:g.40713845G>C
CLNSRC	UniProtKB (protein)
CLNACC	RCV000032472.2,

[PMID 18412265] Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.