[PMID 20639878] A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
People with one or two copies of the G allele at this SNP are 3.5 times more likely to suffer liver injury than TT carriers when taking the prescription nonsteroidal anti-inflammatory drug (NSAID) lumiracoxib. This new pain medication was approved in Europe in late 2006, but because of a higher incidence of liver injury and patient deaths than among patients using other NSAIDs, it was withdrawn from the market in most countries. It is still sold in some countries under the brand names Prexige and Joicela.
[PMID 17660530] Risk alleles for multiple sclerosis identified by a genomewide study.
[PMID 20546594
] An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.
[PMID 26083016] Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups
] An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.
