rs3129878

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)		normal risk for infertility in Chinese men
(A;C)	1.2	1.36 slightly higher risk for infertility in Chinese men
(C;C)	1.3	>1.36 higher risk for infertility in Chinese men

Reference

GRCh38 38.1/141

Chromosome

6

Position

32440958

Gene

HLA-DRA

is a	snp
is	mentioned by
dbSNP	rs3129878
dbSNP (classic)	rs3129878
ClinGen	rs3129878
ebi	rs3129878
HLI	rs3129878
Exac	rs3129878
Gnomad	rs3129878
Varsome	rs3129878
LitVar	rs3129878
Map	rs3129878
PheGenI	rs3129878
Biobank	rs3129878
1000 genomes	rs3129878
hgdp	rs3129878
ensembl	rs3129878
geneview	rs3129878
scholar	rs3129878
google	rs3129878
pharmgkb	rs3129878
gwascentral	rs3129878
openSNP	rs3129878
23andMe	rs3129878
SNPshot	rs3129878
SNPdbe	rs3129878
MSV3d	rs3129878
GWAS Ctlg	rs3129878

GMAF

0.3108

Max Magnitude

1.3

rs3129878 is a SNP in the HLA gene region. It has been associated with slightly (~30%) higher risk for azoospermia (lack of sperm) and thus male infertility in both Chinese and Japanese men.[PMID 22541561][PMID 23934009]

?	(A;A) (A;C) (C;C)	28

[PMID 23934009] HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients

[PMID 19846760] Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

[PMID 22541561] A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.