rs2857595

Orientation

minus

Stabilized

minus

Make rs2857595(C;C)

Make rs2857595(C;T)

Make rs2857595(T;T)

Reference

GRCh38 38.1/141

Chromosome

6

Position

31600692

is a	snp
is	mentioned by
dbSNP	rs2857595
dbSNP (classic)	rs2857595
ClinGen	rs2857595
ebi	rs2857595
HLI	rs2857595
Exac	rs2857595
Gnomad	rs2857595
Varsome	rs2857595
LitVar	rs2857595
Map	rs2857595
PheGenI	rs2857595
Biobank	rs2857595
1000 genomes	rs2857595
hgdp	rs2857595
ensembl	rs2857595
geneview	rs2857595
scholar	rs2857595
google	rs2857595
pharmgkb	rs2857595
gwascentral	rs2857595
openSNP	rs2857595
23andMe	rs2857595
SNPshot	rs2857595
SNPdbe	rs2857595
MSV3d	rs2857595
GWAS Ctlg	rs2857595

GMAF

0.3246

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

[PMID 20662065] Genome-wide association study of cardiac manifestations of neonatal lupus identifies candidate loci at 6p21 and 21q22

GWAS snp
PMID	[PMID 21946350]
Trait
Title	Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Risk Allele	G
P-val	2E-10
Odds Ratio	0.0370 [0.025-0.049] unit increase

[PMID 22134093] Polymorphisms and noncardioembolic stroke in three case-control studies

[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

[PMID 18309376] Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus.

[PMID 19143814] Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.

[PMID 20017995] A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.

GWAS snp
PMID	[PMID 23284291]
Trait	Pulmonary function (interaction)
Title	Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Risk Allele
P-val	8E-8
Odds Ratio	NR NR

GWAS snp
PMID	[PMID 25194280]
Trait	laryngeal squamous cell carcinoma in Chinese
Title	To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively.
Risk Allele
P-val
Odds Ratio