| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
2.9x risk of type-1 diabetes
|
| (C;G)
|
|
1.3x risk of type-1 diabetes
|
| (G;G)
|
0
|
normal
|
rs2296336 has been reported in a Swedish study to be associated with type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.3 (CI 1.00-1.69), and for homozygotes, 2.9 (CI 1.88-4.59). [PMID 16960798
]
[PMID 18340361] suggests this SNP does not play a direct role in type-1 diabetes, and was only seen in the previous study due to being in linkage disequilibrium with specific alleles of the HLA DQB1 gene.
[PMID 19143813] Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
]
