rs2275913

plus

Geno	Mag	Summary
(A;A)		3x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation
(A;G)		1.4x increased gastric cancer risk. Increased risk of Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation
(G;G)		normal

Reference

GRCh38 38.1/141

Chromosome

6

Position

52186235

Gene

IL17A

is a	snp
is	mentioned by
dbSNP	rs2275913
dbSNP (classic)	rs2275913
ClinGen	rs2275913
ebi	rs2275913
HLI	rs2275913
Exac	rs2275913
Gnomad	rs2275913
Varsome	rs2275913
LitVar	rs2275913
Map	rs2275913
PheGenI	rs2275913
Biobank	rs2275913
1000 genomes	rs2275913
hgdp	rs2275913
ensembl	rs2275913
geneview	rs2275913
scholar	rs2275913
google	rs2275913
pharmgkb	rs2275913
gwascentral	rs2275913
openSNP	rs2275913
23andMe	rs2275913
SNPshot	rs2275913
SNPdbe	rs2275913
MSV3d	rs2275913
GWAS Ctlg	rs2275913

GMAF

0.315

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

rs2275913, also known as G-197A, is a SNP in the IL17A gene.

A study of 811 Japanese subjects (524 without gastric cancer and 287 with gastric cancer) reported an odds ratio of 1.42 (CI: 1.09-1.85, p=0.01) for the rs2275913(A) allele, and 3.02 (CI: 1.86-4.91, p<0.0001) for the (A;A) genotype, with gastric cancer.[PMID 19414056]

[PMID 19724898] Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa

[PMID 20437253] The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis

This "A"-allele of this SNP is also functionally associated with acute Graft-Versus-Host Disease after unrelated bone marrow transplantation 10.1371/journal.pone.0026229

[PMID 22028838 ] A Genetic Variant in the IL-17 Promoter Is Functionally Associated with Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation

[PMID 22118860] Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese - A case control study

[PMID 22483685] Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population

[PMID 22461912 ] Association Analysis of IL-17A and IL-17F Polymorphisms in Chinese Han Women with Breast Cancer

[PMID 17828618] The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis.

[PMID 19208686] Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New Zealand.

[PMID 19235914 ] Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.

[PMID 20620187] Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behcet's disease in a Chinese Han population.

[PMID 21217785] A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT.

[PMID 22692973] Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population.

[PMID 23049595 ] Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women

[PMID 23131423] Interleukin-17A genetic variants can confer resistance to brucellosis in Iranian population

[PMID 23376081] Analysis of IL-17 gene polymorphisms in Chinese patients with dilated cardiomyopathy

[PMID 23652560] Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

[PMID 23137879] Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis

[PMID 23485736] Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population

[PMID 24315816] Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population

[PMID 22537748] Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.

[PMID 22559912] Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome.

[PMID 22816799] Association of interleukin-17A and -17F gene single-nucleotide polymorphisms with autoimmune thyroid diseases.

[PMID 22955700] Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.

[PMID 23219503] The IL-17F sequence variant is associated with susceptibility to tuberculosis.

[PMID 23280722] IL17A gene polymorphisms, serum IL-17A and IgE levels, and hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection.

[PMID 23778030] The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.

[PMID 24857622] IL-17F but not IL-17A gene polymorphism confers risk to multiple sclerosis in a Chinese Han population

[PMID 24919468] Influence of the IL17A locus in giant cell arteritis susceptibility

[PMID 25012243] IL-17 gene polymorphism is associated with susceptibility to gastric cancer

[PMID 25227691 ] Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women

[PMID 25374195] Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

[PMID 25680555] Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression

[PMID 25857634] Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F genes differently affect the risk for Tuberculosis in Croatian population

[PMID 25871515] Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population

[PMID 25595174] Specific association of IL17A genetic variants with panuveitis

[PMID 26339129 ] The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

[PMID 26337284] Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients

[PMID 26400516] Interleukin-17 gene polymorphisms in patients with post-transplant diabetes mellitus

[PMID 26436389] Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease

[PMID 26447633] Influence of the IL17A and IL17F genes polymorphisms on the long-term kidney allograft function and return to dialysis after kidney transplantation

[PMID 26467330] Interleukin-17 and leptin genes polymorphisms and their levels in relation to recurrent pregnancy loss in Egyptian females

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

[PMID 26515887] Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis

[PMID 26535650] Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer

[PMID 26535675] Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer

[PMID 26546176] Association of IL-17A and IL-17F gene polymorphisms with chronic hepatitis B and hepatitis B virus-related liver cirrhosis in a Chinese population: A case-control study

[PMID 29050281 ] IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population.

[PMID 29194748] Interleukin-17 and Toll -like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthrits.

[PMID 29262579 ] The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke.

[PMID 29530464] Role of gene polymorphisms/haplotypes and serum levels of interleukin-17A in susceptibility to viral myocarditis.

[PMID 29689450] Association of interleukin-17A polymorphisms with the risk of colorectal cancer: A case-control study.

[PMID 29933861] Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: An updated meta-analysis.

[PMID 30130760] Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization.

[PMID 30275190] IL-8-251T>A (rs4073) Polymorphism Is Associated with Prognosis in Gastric Cancer Patients.

[PMID 30446888] Association Between the Interleukin-17 Gene Polymorphism -197G>A and the Risk of Prostate Cancer in a Galician Population.

[PMID 30655311 ] Correlations of IL-17 and NF-κB gene polymorphisms with susceptibility and prognosis in Acute Respiratory Distress Syndrome in a Chinese population.

[PMID 31042000] Alternative Interleukin (IL)17A/F Locus Haplotypes are associated with increased risk to hip and knee osteoarthritis.

[PMID 31845023] Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis.

[PMID 32185238 ] Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.

[PMID 32294519] Association of Interleukin-17 gene polymorphisms with susceptibility to chronic hepatitis B virus infection and clearance in iranian population.

[PMID 32425678 ] Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy.

[PMID 32543936] Impact of IL-17F 7488T/C Functional Polymorphism on Progressive Rheumatoid Arthritis: Novel Insight from the Molecular Dynamic Simulations.

[PMID 32602796] Association of Polymorphisms in Cytokine genes with susceptibility to Precancerous Lesions and Cervical Cancer: A systematic review with meta-analysis.

[PMID 33000536] Interleukin 17A gene variations and lung function at school age after bronchiolitis in infancy.

[PMID 33559820] Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect of smoking habits in the association with periodontitis and type 2 diabetes mellitus.