Rs2201841
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs2201841 |
| hapmap | rs2201841 |
| hgdp | rs2201841 |
| ensembl | rs2201841 |
| gopubmed | rs2201841 |
| scholar | rs2201841 |
| rs2201841 | |
| pharmgkb | rs2201841 |
| medrefsnp | rs2201841 |
| 23andMe | rs2201841 |
| Gene | IL23R |
| Chromosome | 1 |
| Position | 67466790 |
| Genotype | Effect |
|---|---|
| rs2201841(C;C)* | 1.5x risk for Crohn's disease |
| rs2201841(C;T)* | 1.5x risk for Crohn's disease; 2x risk for Graves' disease |
| rs2201841(T;T)* | 2.4x risk for Graves' disease |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs2201841(A;A) | 22 |
SNP rs2201841, in the IL23R gene, is associated with increased risk for Crohn's disease in both Jewish and non-Jewish populations. [PMID 17068223]
Another study found that the "A allele" and "AA genotype" were significantly overrepresented in Graves' disease patients with Graves ophthalmopathy, based on 216 North American patients. The odds ratios reported were 2.04 for the allele (p=1x10-4), and for the so-called "AA" genotype (presumably rs2201841(T;T) when correctly oriented to the dbSNP orientation), 2.4 (p=1x10-4).[PMID 18073300]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs2201841 |
| PubMedID | [PMID 17804789] |
| Condition | Crohn's disease |
| Gene | IL23R |
| Risk Allele | |
| pValue | 1.00E-008 |
| OR | 1.38 |
| 95% CI | 1.23-1.53 |
