SNP rs1800437, located in the coding region of the GIPR gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele. [PMID 17624916]
[PMID 19254363
] Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.
[PMID 20081857] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
[PMID 20516203] Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.
| GWAS snp
|
| PMID
|
[PMID 23563607]
|
| Trait
|
Obesity
|
| Title
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
| Risk Allele
|
G
|
| P-val
|
3E-14
|
| Odds Ratio
|
1.10 [NR]
|
[PMID 24446656] A Functional Amino Acid Substitution in the Glucose-dependent Insulinotropic Polypeptide-Receptor (GIPR) Gene is Associated with Lower Bone Mineral Density and Increased Fracture risk
] Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.
