rs1799913

heroin addiction in hispanics

minus

Geno	Mag	Summary
(C;C)	1.1	Hispanics may be at increased risk of heroin addiction.

Make rs1799913(A;A)

Make rs1799913(A;C)

Reference

GRCh38 38.1/141

Chromosome

11

Position

18025708

Gene

TPH1

is a	snp
is	mentioned by
dbSNP	rs1799913
dbSNP (classic)	rs1799913
ClinGen	rs1799913
ebi	rs1799913
HLI	rs1799913
Exac	rs1799913
Gnomad	rs1799913
Varsome	rs1799913
LitVar	rs1799913
Map	rs1799913
PheGenI	rs1799913
Biobank	rs1799913
1000 genomes	rs1799913
hgdp	rs1799913
ensembl	rs1799913
geneview	rs1799913
scholar	rs1799913
google	rs1799913
pharmgkb	rs1799913
gwascentral	rs1799913
openSNP	rs1799913
23andMe	rs1799913
SNPshot	rs1799913
SNPdbe	rs1799913
MSV3d	rs1799913
GWAS Ctlg	rs1799913

GMAF

0.3581

Max Magnitude

1.1

commonly referred to as A779C

Only for Hispanics, individuals who have a genoset composed of rs1799913(C;C) and rs7963720(T;T) are reported to be at 14x higher risk for developing heroin addiction (CI:0.83-244.63, p=0.012).[PMID 18181017]

Again, only for Hispanics, individuals having a genoset composed of rs1799913(C;C) and rs4290270(T;T) are reported to be at 9x higher risk for developing heroin addiction (CI:0.5-153, p=0.063).[PMID 18181017]

OMIM	608516
Desc	MAJOR DEPRESSIVE DISORDER; MDD
Variant
Related	also

OMIM	191060
Desc	TRYPTOPHAN HYDROXYLASE 1; TPH1
Variant
Related	also

[PMID 17521439 ] Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.

[PMID 20580984] Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.