| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
normal
|
| (C;G)
|
1.5
|
1.3x higher risk for Crohn's disease
|
| (G;G)
|
2
|
1.9x higher risk for Crohn's disease
|
rs17221417 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.29 (CI 1.13-1.46), and for homozygotes, 1.92 (CI 1.58-2.34). [PMID 17554300
]
| OMIM | 605956 |
| Desc | NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN PROTEIN 2; NOD2 |
| Variant | |
| Related | also |
[PMID 18843111] Individual disease risk and multimetric analysis of Crohn disease.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 28506689] Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.
]
