rs1328674
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | higher risk for RA | |
| (A;G) | higher risk for RA | |
| (G;G) | 0 | average |
| Reference | GRCh38 38.1/141 |
| Chromosome | 13 |
| Position | 46867572 |
| Gene | HTR2A |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1328674 |
| dbSNP (classic) | rs1328674 |
| ClinGen | rs1328674 |
| ebi | rs1328674 |
| HLI | rs1328674 |
| Exac | rs1328674 |
| Gnomad | rs1328674 |
| Varsome | rs1328674 |
| LitVar | rs1328674 |
| Map | rs1328674 |
| PheGenI | rs1328674 |
| Biobank | rs1328674 |
| 1000 genomes | rs1328674 |
| hgdp | rs1328674 |
| ensembl | rs1328674 |
| geneview | rs1328674 |
| scholar | rs1328674 |
| rs1328674 | |
| pharmgkb | rs1328674 |
| gwascentral | rs1328674 |
| openSNP | rs1328674 |
| 23andMe | rs1328674 |
| SNPshot | rs1328674 |
| SNPdbe | rs1328674 |
| MSV3d | rs1328674 |
| GWAS Ctlg | rs1328674 |
| GMAF | 0.0528 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1328674 is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs1328674(A) in dbSNP orientation. The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). This is actually quite close to the odds ratio calculated for rs1328674 by itself; OR of 1.62 (p = 0.007). [PMID 18006541]
Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above should be CACC, rather than CTCC as published.
