[PMID 20235787] Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins
| GWAS snp
|
| PMID
|
[PMID 20864672 ]
|
| Trait
|
|
| Title
|
Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|
| Risk Allele
|
T
|
| P-val
|
1E-11
|
| Odds Ratio
|
0.02 [0.01-0.03] unit decrease
|
| GWAS snp
|
| PMID
|
[PMID 20686565]
|
| Trait
|
|
| Title
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
| Risk Allele
|
C
|
| P-val
|
5.6E-45
|
| Odds Ratio
|
2.4500 None
|
[PMID 19682379] TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.
[PMID 19913121] Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
[PMID 20578904] Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.
http://www.medscape.com/viewarticle/832327
Each additional allele of rs17238484(G) was associated with a mean 0.06-mmol/L lower LDL-cholesterol level. Similar reductions were associated with rs12916 SNP. In addition, they found that each additional allele of rs17238484-G was associated with a higher body weight (0.30 kg), waist circumference (0.32 cm), and plasma insulin concentration (1.62%) and plasma glucose concentration (0.23%). Again, the rs12916 SNP had similar effect
[PMID 25262344] HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
[PMID 29165714] Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study.
[PMID 33167740] Association of NCP1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease.
]
