In a survey that scanned 80 genes, no SNPs with a large effect were found to be associated with bipolar disorder. However, the SNP with the largest association was rs1170191, in first intron of the diacylglycerol kinase eta DGKH gene. The odds ratio for the risk allele of this SNP is 1.59 (p = 1.5x10e-8, experiment-wide p<0.01).[PMID 17486107
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[PMID 18421293] Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.
[PMID 19308021] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
[PMID 19818381] Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
[PMID 22048461] Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.
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