Rs1136287
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs1136287 |
| hapmap | rs1136287 |
| hgdp | rs1136287 |
| ensembl | rs1136287 |
| gopubmed | rs1136287 |
| scholar | rs1136287 |
| rs1136287 | |
| pharmgkb | rs1136287 |
| medrefsnp | rs1136287 |
| 23andMe | rs1136287 |
| Gene | SERPINF1 |
| Chromosome | 17 |
| Position | 1620026 |
| Genotype | Effect |
|---|---|
| rs1136287(C;C) | normal |
| rs1136287(C;T)* | 1.5x increased risk of wet ARMD |
| rs1136287(T;T) | 3.9x increased risk of wet ARMD |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs1136287(C;C) | 00 | |
| Rs1136287(T;T) | 2.22.2 |
rs1136287, also known as Met72Thr, is a SNP in the PEDF gene.
Analysis of 86 Taiwanese Chinese patients with wet age related macular degeneration (ARMD) found the (T) allele to be more frequent in patients than in controls (50% vs 31%; p =.0005). The rs1136287(T;T) genotype was also more prevalent in patients than in controls (odds ratio 3.9, p = .0015).[PMID 18226801]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
