From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2.1
|
2.15x more likely positive lymph node
|
| (A;G)
|
|
|
| (G;G)
|
0
|
more favorable
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
This SNP in can have implications for prognosis in
breast cancer.
It is located 313 base pairs upstream of the 5'-untranslated region of SIPA1 and is considered to be within the promoter region of the gene.
SIPA1 germline polymorphisms are associated with aggressive disease behavior(lymph node metastasis) in the cohort examined
[PMID 19906411] Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer
