Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the rs9298506(A) allele has been associated with higher risk of aneurysm, with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). [PMID 20364137]
|Title||Susceptibility loci for intracranial aneurysm in European and Japanese populations|
|Odds Ratio||1.35 [1.22-1.49]|
[PMID 17903302] Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23733552] Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.