Rs9298506

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs9298506
PheGenI	rs9298506
nextbio	rs9298506
hapmap	rs9298506
1000 genomes	rs9298506
hgdp	rs9298506
ensembl	rs9298506
gopubmed	rs9298506
geneview	rs9298506
scholar	rs9298506
google	rs9298506
pharmgkb	rs9298506
gwascentral	rs9298506
openSNP	rs9298506
23andMe	rs9298506
23andMe all	rs9298506
SNP Nexus
SNPshot	rs9298506
SNPdbe	rs9298506
MSV3d	rs9298506

Gene

SEC11B

Chromosome

8

Orientation

plus

GMAF

0.1877

Position

55437524

Reference

GRCh37.p2 37.2/134

Max Magnitude

0

Geno	Mag	Summary
(A;A)	0

Make rs9298506(A;G)

Make rs9298506(G;G)

?	(A;A) (A;G) (G;G)	28

Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the rs9298506(A) allele has been associated with higher risk of aneurysm, with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). [PMID 20364137]

GWAS snp
PMID	[PMID 18997786]
Trait	Intracranial aneurysm
Title	Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele	A
P-val	2E-9
Odds Ratio	1.35 [1.22-1.49]

OMIM	612587
Desc
Variant
Related	also

[PMID 17903302] Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.

GET Evidence
rs9298506
aa_change
aa_change_short
impact	pathogenic
qualified_impact	Insufficiently evaluated pathogenic
overall_frequency	0.210938
summary

Brain Aneurysm