Rs9298506

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Orientationplus
Geno Mag Summary
(A;A) 0 Higher Risk Aneurysm
Make rs9298506(A;G)
Make rs9298506(G;G)
ReferenceGRCh38 38.1/141
Chromosome8
Position54524964
GeneSEC11B
is asnp
is mentioned by
dbSNPrs9298506
PheGenIrs9298506
nextbiors9298506
hapmaprs9298506
1000 genomesrs9298506
hgdprs9298506
ensemblrs9298506
gopubmedrs9298506
geneviewrs9298506
scholarrs9298506
googlers9298506
pharmgkbrs9298506
gwascentralrs9298506
openSNPrs9298506
23andMers9298506
23andMe allrs9298506
SNP Nexus

SNPshotrs9298506
SNPdbers9298506
MSV3drs9298506
GMAF0.1878
Max Magnitude0
? (A;A) (A;G) (G;G) 28
Based on a large study (~6,000 cases and 14,000 controls) of both European and Japanese populations, the rs9298506(A) allele has been associated with higher risk of aneurysm, with an odds ratio per allele of 1.28 (CI:1.20-1.38, p=1.0e-06). [PMID 20364137OA-icon.png]
GWAS snp
PMID [PMID 18997786OA-icon.png]
Trait Intracranial aneurysm
Title Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele A
P-val 2E-9
Odds Ratio 1.35 [1.22-1.49]


OMIM612587
Desc
Variant
Relatedalso
[PMID 17903302OA-icon.png] Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.


GET Evidence
rs9298506
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.210938
summary



Brain Aneurysm


[PMID 23733552OA-icon.png] Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.


[PMID 25053769] Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain