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rs8179183 is a SNP in the leptin receptor LEPR gene.
In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs8179183(G) allele were less likely to gain significant weight compared to rs8179183(C;C) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs6837793 and rs705381, were also significantly associated with weight profiles in these patients.[PMID 17199131]
[PMID 20032477] Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults
[PMID 21512510] The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents
[PMID 15113403] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.
[PMID 15157284] Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.
[PMID 18212354] Genes in glucose metabolism and association with spina bifida.
[PMID 18254975] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
[PMID 18426866] Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 20149225] Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis.
[PMID 21393862] A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23284729] Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
[PMID 22975643] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.
[PMID 22983835] The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis.