Rs8179183
| Orientation | plus |
| is a | snp |
| is | mentioned by |
| dbSNP | rs8179183 |
| PheGenI | rs8179183 |
| nextbio | rs8179183 |
| hapmap | rs8179183 |
| 1000 genomes | rs8179183 |
| hgdp | rs8179183 |
| ensembl | rs8179183 |
| gopubmed | rs8179183 |
| geneview | rs8179183 |
| scholar | rs8179183 |
| rs8179183 | |
| pharmgkb | rs8179183 |
| gwascentral | rs8179183 |
| openSNP | rs8179183 |
| 23andMe | rs8179183 |
| 23andMe all | rs8179183 |
| SNP Nexus | |
| SNPshot | rs8179183 |
| SNPdbe | rs8179183 |
| MSV3d | rs8179183 |
| Gene | LEPR |
| Chromosome | 1 |
| Orientation | plus |
| GMAF | 0.1451 |
| Position | 66075952 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal | |
| (C;G) | less likely to gain weight if taking risperidone | |
| (G;G) | less likely to gain weight if taking risperidone |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs8179183(G) allele were less likely to gain significant weight compared to rs8179183(C;C) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs6837793 and rs705381, were also significantly associated with weight profiles in these patients.[PMID 17199131]
[PMID 20032477] Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults
[PMID 21512510] The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents
[PMID 15113403] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.
[PMID 15157284] Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.
[PMID 18212354] Genes in glucose metabolism and association with spina bifida.
[PMID 18254975] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
[PMID 18426866] Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 20149225] Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis.
[PMID 21393862] A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.
| GET Evidence | |
|---|---|
| LEPR-K656N | |
| aa_change | Lys656Asn |
| aa_change_short | K656N |
| impact | not reviewed |
| qualified_impact | Insufficiently evaluated not reviewed |
| overall_frequency | 0.176224 |
| summary | |
[PMID 23284729] Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
