Rs8179183

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Merged intors1805094
Orientationplus
is asnp
is mentioned by
dbSNPrs8179183
PheGenIrs8179183
nextbiors8179183
hapmaprs8179183
1000 genomesrs8179183
hgdprs8179183
ensemblrs8179183
gopubmedrs8179183
geneviewrs8179183
scholarrs8179183
googlers8179183
pharmgkbrs8179183
gwascentralrs8179183
openSNPrs8179183
23andMers8179183
23andMe allrs8179183
SNP Nexus

SNPshotrs8179183
SNPdbers8179183
MSV3drs8179183
StatusMerged into rs1805094
GeneLEPR
Chromosome1
Orientationplus
GMAF0.1451
Position66075952
ReferenceGRCh37 37.1/131
Max Magnitude
Geno Mag Summary
(C;C) normal
(C;G) less likely to gain weight if taking risperidone
(G;G) less likely to gain weight if taking risperidone
? (C;C) (C;G) (G;G) 28
rs8179183 is a SNP in the leptin receptor LEPR gene.

In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs8179183(G) allele were less likely to gain significant weight compared to rs8179183(C;C) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs6837793 and rs705381, were also significantly associated with weight profiles in these patients.[PMID 17199131]

OMIM601007
DescLEPTIN RECEPTOR POLYMORPHISM
Variant0005
Relatedalso


[PMID 20032477] Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults


[PMID 21512510] The Effect of Ponderal Index at Birth on the Relationships Between Common LEP and LEPR Polymorphisms and Adiposity in Adolescents


[PMID 15113403OA-icon.png] Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.


[PMID 15157284OA-icon.png] Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.


[PMID 18212354OA-icon.png] Genes in glucose metabolism and association with spina bifida.


[PMID 18254975OA-icon.png] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.


[PMID 18426866OA-icon.png] Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 20149225OA-icon.png] Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis.


[PMID 21393862OA-icon.png] A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children.


GET Evidence
LEPR-K656N
aa_change Lys656Asn
aa_change_short K656N
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.176224
summary



[PMID 23284729OA-icon.png] Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits


[PMID 22975643] Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training.


[PMID 22983835] The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis.