| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal risk
|
| (A;C)
|
|
1.7x increased risk for prostate cancer
|
| (C;C)
|
|
1.7x increased risk for prostate cancer
|
rs7017300 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295.[PMID 17925536]
In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.[PMID 17925536]
[PMID 21086507] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)
[PMID 18670647
] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18704501] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
[PMID 21456070] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).
[PMID 23532531] Common Variants at 8q24 are Associated with Prostate Cancer Risk in Serbian Population
] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
