Initial reports of a link to schizophrenia remain inconclusive.
paper implicated in schizophrenia
[PMID 17925794] effects white matter density and integrity
[PMID 19058791] T allele (in a per allele fashion) significantly associated with lateral ventricle volume in 95 first-episode schizophrenics
[PMID 19339916] points out that their result is that (T) was weakly associated with schizophrenia, however this is the opposite of the original association study where the C allele.
[PMID 19913623] Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia
[PMID 21745728] Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population
[PMID 17598910] Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.
[PMID 17884806] Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1.
[PMID 18543275] A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.
[PMID 19448847] Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
[PMID 19521112] Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.
[PMID 19594860] Genes for psychosis and creativity: a promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement.
[PMID 21035784] The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males.
[PMID 23360725] Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample
[PMID 24865593] Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children
[PMID 24123921] Effects of neuregulin-1 genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees
[PMID 25802071] Two functional promoter polymorphisms of neuregulin 1 gene are associated with progressive forms of multiple sclerosis