Rs6994992

Orientation

plus

is a	snp
is	mentioned by
dbSNP	rs6994992
PheGenI	rs6994992
nextbio	rs6994992
hapmap	rs6994992
1000 genomes	rs6994992
hgdp	rs6994992
ensembl	rs6994992
gopubmed	rs6994992
geneview	rs6994992
scholar	rs6994992
google	rs6994992
pharmgkb	rs6994992
gwascentral	rs6994992
openSNP	rs6994992
23andMe	rs6994992
23andMe all	rs6994992
SNP Nexus
SNPshot	rs6994992
SNPdbe	rs6994992
MSV3d	rs6994992

Gene

NRG1

Chromosome

8

Orientation

plus

GMAF

0.4409

Position

31495581

Reference

GRCh37 37.1/131

Max Magnitude

1

Geno	Mag	Summary
(C;T)	1
(T;T)	1	increased creativity?

Make rs6994992(C;C)

also known as SNP8NRG243177

Initial reports of a link to schizophrenia remain inconclusive.

paper implicated in schizophrenia

[PMID 17925794] effects white matter density and integrity

[PMID 17565985] schizophrenia risk-associated

[PMID 18286587] The neuregulin 1 promoter polymorphism rs6994992 is not associated with neurocognition or chronic schizophrenia in a study of 738 patients

[PMID 19058791] T allele (in a per allele fashion) significantly associated with lateral ventricle volume in 95 first-episode schizophrenics

[PMID 19339916] points out that their result is that (T) was weakly associated with schizophrenia, however this is the opposite of the original association study where the C allele.

OMIM	142445
Desc	NEUREGULIN 1; NRG1
Variant
Related	also

[PMID 19913623] Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia

[PMID 21745728] Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population

[PMID 17598910] Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.

[PMID 17884806] Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1.

[PMID 18543275] A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia.

[PMID 19448847] Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.

[PMID 19521112] Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.

[PMID 19594860] Genes for psychosis and creativity: a promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement.

[PMID 21035784] The influence of schizophrenia-related neuregulin-1 polymorphisms on sensorimotor gating in healthy males.