Rs6920220

From SNPedia

rs6920220 has been reported in a large study to be associated with rheumatoid arthritis.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.20 (CI 1.06-1.36), and for homozygotes, 1.72 (CI 1.33-2.22). [PMID 17554300]

[PMID 19417005] rheumatoid arthritis

• rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)].
• rs5029937
• rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194

The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)

[PMID 19401279] Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis

GWAS snp
PMID	[PMID 18794853]
Trait	Rheumatoid arthritis
Title	Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Risk Allele
P-val	2E-9
Odds Ratio	1.24 [1.16-1.32]

GWAS snp
PMID	[PMID 17982456]
Trait	Rheumatoid arthritis
Title	Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Risk Allele
P-val	9.9999999999999995E-8
Odds Ratio	1.22 [NR]

[PMID 19565500] Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis