Rs664143

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Orientationminus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.6x increased risk of lung cancer
(T;T) 1.6x increased risk of lung cancer
ReferenceGRCh38 38.1/141
Chromosome11
Position108354934
GeneATM, C11orf65
is asnp
is mentioned by
dbSNPrs664143
PheGenIrs664143
nextbiors664143
hapmaprs664143
1000 genomesrs664143
hgdprs664143
ensemblrs664143
gopubmedrs664143
geneviewrs664143
scholarrs664143
googlers664143
pharmgkbrs664143
gwascentralrs664143
openSNPrs664143
23andMers664143
23andMe allrs664143
SNP Nexus

SNPshotrs664143
SNPdbers664143
MSV3drs664143
GMAF0.404
Max Magnitude0
? (C;C) (C;T) (T;T) 28

600+ Korean lung cancer patients were part of a study that concluded that the rs664143(T) allele, as oriented vis-a-vis dbSNP, located in the ATM gene and also known as IVS62+60G>A, was associated with increased risk, with an odds ratio of 1.68 (CI: 1.1-2.1, p<0.05).[PMID 16497724]

In a study of 119 American patients with potentially resectable pancreatic cancer, the rs664143(C) allele was associated with poorer overall survival (ie response) to combined gerncitabine radiation therapy. Also, as 1 of 3 SNPs its risk allele is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy; median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004). [PMID 18381943OA-icon.png]


[PMID 21058196] Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk


[PMID 22203481] Association between ATM polymorphisms and cancer risk: a meta-analysis


[PMID 12466288OA-icon.png] Haplotype and linkage disequilibrium architecture for human cancer-associated genes.


[PMID 17132159OA-icon.png] Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.


[PMID 17151932] Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma.


[PMID 17431766] Two-stage case-control study of common ATM gene variants in relation to breast cancer risk.


[PMID 19115993OA-icon.png] Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.


[PMID 19536092OA-icon.png] Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.


[PMID 19584272OA-icon.png] Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.


[PMID 25196645] Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma