Rs6458307

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is asnp
is mentioned by
dbSNPrs6458307
hapmaprs6458307
hgdprs6458307
ensemblrs6458307
gopubmedrs6458307
scholarrs6458307
googlers6458307
pharmgkbrs6458307
hgvbaseg2prs6458307
medrefsnprs6458307
23andMers6458307
SNP Nexus

Chromosome6
Orientationplus
Position42839092
GenotypeEffect
rs6458307(C;C)1.4x risk
rs6458307(C;T)0.8x risk
rs6458307(T;T)normal


Genotypes Magnitude Summary
Rs6458307(C;C) 00 1.4x risk
Rs6458307(C;T) 0.8x risk
Rs6458307(G;G) 00
Rs6458307(T;T) normal
rs6458307 has been reported in a large study to be associated with bipolar disorder.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.84 (CI 0.75-0.96), and for homozygotes, 1.39 (CI 1.13-1.69). [PMID 17554300]

? (C;C) (C;T) (T;T)
GWAS
SNP rs6458307
PubMedID [PMID 17554300]
Condition Bipolar disorder
Gene NR
Risk Allele
pValue 4.00E-006
OR 1.19
95% CI 1.04-1.33


PharmGKBPA162356506
Name
AnnotationGWAS results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR). This variant is associated with Bipolar disorder.
Gene-
Featue
EvidencePubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
Drugs
DiseasesBipolar Disorder
Curation LevelNon-Curated