Rs6457617

rs6457617 has been reported in a large study to be associated with rheumatoid arthritis. This SNP is reported to be the most statistically significant of many SNPs similarly located in the MHC region.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 2.36 (CI 1.97-2.84), and for homozygotes, 5.21 (CI 4.31-6.30). [PMID 17554300]

GWAS snp
PMID	[PMID 18668548]
Trait	Rheumatoid arthritis
Title	Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
Risk Allele
P-val	1.0000000000000001E-9
Odds Ratio	NR NR

[PMID 19714643] TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians

GWAS snp
PMID	[PMID 20383147]
Trait	Systemic sclerosis
Title	Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Risk Allele
P-val	4E-17
Odds Ratio	1.37 [1.28-1.47]

[PMID 21750679] Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis

GWAS snp
PMID	[PMID 21841780]
Trait
Title	A genome-wide association study identifies two new risk loci for Graves' disease.
Risk Allele	T
P-val	7E-33
Odds Ratio	1.4000 [1.32-1.48]

[PMID 22355377] Caucasian and asian specific rheumatoid arthritis risk Loci reveal limited replication and apparent allelic heterogeneity in north indians