From SNPedia
rs6060369 is a SNP associated with a (slight) increase in height, in that individuals tend to be 0.44cm taller for each
rs6060369(C) allele they carry. This finding was statistically significant (p=9.7x10e-7), and ultimately tested in over 28,000 individuals.[
PMID 18193045]
A haplotype of rs6060369 and rs143383, a neighboring SNP in the GDF5 gene, can be defined, which also links height to osteoarthritis since rs143383 has previously been linked to osteoarthritis.[PMID 18193045]
Medpage article
| ? | (C;C) (C;T) (T;T) |
|---|
 |
| GWAS
|
| SNP
| rs6060369
|
| PubMedID
| [PMID 18193045]
|
| Condition
| Height
|
| Gene
| BFZB
|
| Risk Allele
| C
|
| pValue
| 2.00E-016
|
| OR
| 0.44
|
| 95% CI
| NR) cm talle
|
| GWAS snp
|
| PMID
| [PMID 18391950]
|
| Trait
| Height
|
| Title
| Identification of ten loci associated with height highlights new biological pathways in human growth
|
| Risk Allele
| C
|
| P-val
| 9.9999999999999998E-17
|
| Odds Ratio
| 0.44 [0.34-0.72] cm taller
|
Related to STATURE QUANTITATIVE TRAIT LOCUS 14; STQTL14
according to
omim 612228. See
also
| PharmGKB | PA162356726 |
| Name | |
| Annotation | GWAS Results: Common variants in the GDF5-UQCC region are associated with variation in human height (Initial Sample Size: 6,669 individuals; Replication Sample Size: 28,801 individuals). |
| Gene | UQCC |
| Featue | |
| Evidence | PubMed ID:18193045; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | |
| Curation Level | Non-Curated |
