From SNPedia
| longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's. |
| Genotypes |
Magnitude |
Summary |
| Rs5882(A;A) |
00 |
|
| Rs5882(A;G) |
|
lower risk of dementia and Alzheimer's disease |
| Rs5882(G;G) |
2.12.1 |
longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's. |
This SNP has been related to exceptional long life. A study in
Ashkenazi Jews showed that individuals with this genotype have significantly longer lifespans, and better cognitive function [
PMID 17190939])
Another study shows that this homozygote has and average 70% lower risk of dementia and Alzheimer's disease.
